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Author: Admin | 2025-04-28
What are the differences between prednisone and prednisolone?Prednisone and prednisolone are synthetic corticosteroids used for suppressing the immune system and inflammation. Both drugs are used to treat many conditions including arthritis, colitis, asthma, bronchitis, skin problems, and allergies.Corticosteroids including prednisone and prednisolone are commonly used to suppress the immune system and prevent the body from rejecting transplanted organs.Brand names of prednisone include Prednisone Intensol and Rayos. Brand names of prednisolone include Flo-Pred, Pediapred, Orapred, and Orapred ODT.Common side effects of both prednisone and prednisolone include retention of sodium (salt) and fluid, weight gain, high blood pressure (hypertension), potassium loss, headache, muscle weakness, nausea, vomiting, acne, thinning skin, restlessness, and psychiatric disturbances (depression, euphoria, insomnia, mood swings, personality changes, and psychotic behavior).Prolonged use of prednisone or prednisolone can depress the ability of body's adrenal glands to produce corticosteroids. Abruptly stopping prednisone or prednisolone can cause symptoms of corticosteroid insufficiency, such as nausea, vomiting, weakness, fatigue, decreased appetite, weight loss, diarrhea, abdominal pain, and shock. Weaning off prednisone or prednisolone should occur gradually so that the adrenal glands have time to recover and resume production of cortisol.What are prednisone and prednisolone?Prednisone and prednisolone are synthetic (man-made) corticosteroids (steroids) used for suppressing the immune system and inflammation. These drugs have effects similar to other corticosteroids such as triamcinolone (Kenacort), methylprednisolone (Medrol), and dexamethasone (Decadron). These synthetic corticosteroids mimic the action of cortisol (hydrocortisone), the naturally-occurring corticosteroid produced in the body by the adrenal glands. There are numerous preparations of corticosteroids including tablets, capsules,
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