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Author: Admin | 2025-04-28
The.00:06:48 Stephen SmallSo that means that it lower the exposure, which might not be a good thing. And when we’re thinking about other juices, there was actually a 2002 study I found again with only 10 folks.00:07:00 Stephen SmallWhere they got fexofenadine for a dose and they gave these patients up to 1.2 liters of grapefruit, orange apple juice or water.00:07:09 Stephen SmallAnd they gave it over three hours, and it turns out all those juices decrease the AUC there.00:07:14 Stephen SmallBy 30 to 40% also. So I would say the cherry on top here is that we’re not really sure if this made a clinical difference.00:07:23 Stephen SmallSo just because we’re changing drug levels in the body doesn’t mean we actually changed how that drug is actually treating symptoms. For example, they didn’t look at allergy symptoms when these studies, so kind of hard to say.00:07:33 Stephen SmallSo then when it comes to the claim that there are other meds, you can’t take the fruit juices specifically fexofenadine. Here I would say that the verdict is.00:07:45 Stephen SmallTrue, but with conditions probably.00:07:48 Stephen SmallHere’s my thought, Don.00:07:49 Stephen SmallThat it’s.00:07:50 Stephen SmallBut these volumes are pretty astounding and frankly, a little bit aggressive, right?00:07:54 Stephen Small1.2 liters of fruit juice seems really crazy to me.00:07:59 Don WeinbergerYeah.00:08:00 Don WeinbergerFor someone who doesn’t like grapefruit juice, that seems almost.00:08:02 Stephen SmallImpossible. Yeah, that’s your nightmare.00:08:07 Don WeinbergerGood thoughts.00:08:10 Don WeinbergerSo we’ve cherry picked another one here. I warned you folks about the puns.00:08:13 Don WeinbergerYou’re trapped with us.00:08:14 Don WeinbergerSo this one this rumor is can juices affect absorption of ADHD stimulants like Adderall for example?00:08:23 Don WeinbergerYou know this good question, because grabbing a glass of orange juice or apple juice in the morning with an ADHD stimulant medication probably happens a lot.00:08:33 Don WeinbergerAnd yes, it does affect absorption, but not really on the same mechanism as the stats and the grapefruits.00:08:39 Don WeinbergerWere.00:08:41 Don WeinbergerSo the Jews itself, especially ones that have fortified with the vitamin C, can actually work against the stimulant effectiveness.00:08:47 Don WeinbergerFirst, you know juices affect the acidity of the stomach, which actually lowers the absorption of the stimulants.00:08:53 Don WeinbergerBut also second, they increase the acidity of the urine itself.00:08:58 Don WeinbergerWhich increases the amount of stimulant that’s actually excreted from the body.00:09:01 Don WeinbergerSo patients do complain, you know, about the semen is not working.00:09:06 Don WeinbergerIt’s maybe not lasting long throughout the day.00:09:10 Don WeinbergerTheir juice consumption actually may be to blame to ensure proper absorption.00:09:14 Don WeinbergerYou know, maybe prudent to separate those. The juice consumption by either one hour before one hour, 1 hour after taking that medication.00:09:23
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