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Author: Admin | 2025-04-28
Usually preferred.CostsBenadryl and Allegra are both brand-name OTC products. Allegra usually costs more than Benadryl.Both of these products have store-brand versions. Store brands are usually cheaper than the brand-name versions.Benadryl vs. UnisomBenadryl contains the ingredient diphenhydramine, a first-generation antihistamine.There are different forms of Unisom. Most of these also contain the ingredient diphenhydramine. However, one Unisom product contains a similar drug, doxylamine.UsesOral Benadryl products are approved for decreasing symptoms of hay fever and other respiratory allergies, and symptoms of the common cold, such as sneezing and a runny nose. Topical Benadryl products are approved for decreasing pain and itchy skin due to hives, insect bites, and other causes.Although it’s not approved for this purpose, some people take Benadryl to help improve their sleep. Unisom is approved for helping relieve occasional sleeplessness. It’s not intended to be used to treat ongoing or long-term insomnia.Drug formsBenadryl is available in many different forms, including:oral tabletsoral liquid-filled capsules (liqui-gels)oral chewable tabletsoral liquid solutiontopical creamtopical geltopical spraytopical stickOral Benadryl products are usually taken every 4 to 6 hours. Topical Benadryl products are typically used up to four times daily. Oral Benadryl products are not approved for sleeplessness, but some people take oral Benadryl once before bedtime for that purpose.There are also several forms of Unisom products. These include:diphenhydramine-containing products: oral softgels (SleepGels)oral mini capsules (SleepMinis)oral liquidorally disintegrating tablets (SleepMelts)doxylamine-containing product: oral tablets (SleepTabs)These products are usually taken once daily, just before bedtime or at bedtime.Side effects and risksBenadryl and most Unisom products contain the same ingredient, diphenhydramine. One form of Unisom contains a different ingredient, doxylamine. Doxylamine is very similar to diphenhydramine and causes very similar common and serious side effects.The most common side effects of Benadryl and Unisom include:headachedizzinessbody weaknessdry mouthsleepinessSome serious side effects can include:decreased memoryimpaired thinkingconfusionimpaired drivingseizuresfast heartbeatdementiaEffectivenessBenadryl and most forms of Unisom contain the same active ingredient, diphenhydramine. Both products can help people with occasional sleeplessness to fall asleep. This effect may decrease or wear off with continued use.According to clinical guidelines from 2017, diphenhydramine is not recommended to treat ongoing or long-term insomnia.CostsBenadryl and Unisom are both brand-name OTC products. These products usually cost about the same.Both of these products have store-brand versions. Store brands are usually cheaper than the brand-name versions.Benadryl vs. melatoninBenadryl contains the ingredient diphenhydramine, a first-generation antihistamine.Melatonin is a hormone that naturally occurs in the body. It’s involved in regulating the wake-sleep cycle of the body. It’s
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