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Author: Admin | 2025-04-28
Characterization of complexes by DSC and X-ray diffraction studies. To check the superiority of selected superdisintegrants [sodium starch glycolate (SSG), croscarmellose sodium (CCS), crospovidone (CPV)] in enhancing the dissolution rate of TDF. To fasten the onset of action and thereby increasing TDF's bioavailability in comparison to its conventional tablets. Methods: Standard calibration curve of TDF in pH 6.8 phosphate buffer was constructed by spectrophotometric method, drug-excipient compatibility was checked by FT-IR studies. All the Formulations were evaluated for pre-& post-compression studies. Accelerated stability studies up to 3 months were conducted for the optimized formulation, as per ICH guidelines. Results and Discussions: polymers used in the study are compatible with TDF. Pre-& post-compression parameters were within the acceptable limits for all formulations. In vitro dissolution kinetic studies indicate the release of TDF from ODT increases with the increased concentration of superdisintegrants. The order of superdisintegrants in enhancing the dissolution rate of TDF is CPV>SSG>CCS. Formulation F6, had the highest dissolution efficiency at 5 min (DE5=39.55 %); first order dissolution rate constant (K1 =0.1052 min-1) with a regression coefficient (r 2 =0. 9844) and lesser time for 50% of drug release (t50=4 min), was considered as the optimal ODT. It passed the test for stability as per ICH guidelines. Conclusion: The optimized TDF ODT with its 1:4 βCD complex was formulated by the direct compression technique, with 6% w/w CPV as superdisintegrant, which will fasten the onset of action and enhances the bioavailability of TDF in comparison to its conventional tablets.Formulation Development and Evaluation of Tadalafil Transdermal Patches Using Various Penetration EnhancersThe aim of this research study was to develop transdermal Patch of tadalafil using various skin penetration enhancers in different concentrations like Eugenol, 1-Octanol,DMSO and Peppermint oilfor erectile dysfunction and to understand the role of penetration enhancer on the drug delivery in transdermal patch. The physicochemical compatibility and preformulation studies of the drug and the polymers was studied by Infrared spectroscopy and HPLC. Different formulation of transdermal patches using Chitosan 4% w/w as polymer and polyethylene glycol 400 and glycerol (1:1) as plasticizerwere fabricated.The results suggested no physicochemical incompatibility between the drug and the polymers. Formulated patches were evaluated for folding endurance, thickness, weight uniformity, percentage moisture content, percentage moisture uptake, content uniformity in-vitro permeation studies and in-vitro drug release were performed in 50% v/vethanolic phosphate buffer of pH 7.4.The result showed that formulation DMSO-5 found to be best formulation, as it permeated 59.42% drug through rat Dorsal skin as compare of control patch. Overall results of all permeation enhancers stated that DMSO was found to be the best penetration enhancer, as it has the best penetration ability for tadalafil transdermal drug delivery.Transdermal delivery of tadalafil using a novel formulationDrug Delivery,
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