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Author: Admin | 2025-04-28
If you take CONTRAVE with high-fat meals; if you take certain medicines at the same time; if you are already at a higher than usual risk of seizures.Serotonin toxicity (also known as serotonin syndrome): CONTRAVE can cause serotonin toxicity, a rare but potentially life-threatening condition. It can cause serious changes in how your brain, muscles and digestive system work. It is more likely to develop serotonin toxicity when you start taking CONTRAVE or when your dose is increased. It may also occur if you take CONTRAVE with certain antidepressants or migraine medications.Serotonin toxicity symptoms include:fever, sweating, shivering, diarrhea, nausea, vomiting;muscle shakes, jerks, twitches or stiffness, overactive reflexes, loss of coordination, flushing; fast heartbeat, changes in blood pressure;confusion, agitation, restlessness, hallucinations, mood changes, unconsciousness, anxiety, and coma.Severe allergic reaction:CONTRAVE may cause an allergic reaction. Symptoms may include skin rash, hives, swelling of the face or throat, muscle pain, joint pain, difficulty breathing, severe skin reactions, chest pain or fever.If you have an allergic reaction your symptoms may not go away even after you stop takingCONTRAVE. Severe skin reactions: Taking CONTRAVE may cause serious skin reactions. This included StevensJohnson Syndrome (SJS), acute generalised exanthematous pustulosis (AGEP), and erythema multiforme. Stop taking CONTRAVE and get immediate medical help if you experience:severe skin rash peeling of the skinblisters around the mouth, eyes or genitals itchingchest pain swelling shortness of breath body aches feverSystemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE): CONTRAVE has been associated with new or worsening symptoms in patients susceptible to SLE and CLE. These are autoimmune diseases where your body’s immune system attacks your own tissues and organs. Talk to your healthcare professional right away if you have blotchy rashes mainly on the face, fatigue, joint pain, swelling in the joints, muscle pain, rash, swelling, fever, nausea, or loss of appetite.See the Serious side effects and what to do about them table, below, for more information on these and other serious side effects.Alcohol:CONTRAVE lowers your alcohol tolerance. This means you may feel the effects of alcohol when taking less alcohol than usual. Drinking alcohol while taking CONTRAVE may increase your risk of having seizures and allergic reactions. It is best not to drink alcohol at all while taking CONTRAVE to avoid side effects.Pregnancy and Breastfeeding:Do not take CONTRAVE if you are pregnant. Tell your healthcare professional right away if you become pregnant while taking CONTRAVE. They will discuss the risks of birth defects and complications after birth if you take CONTRAVE during pregnancy.Talk to your healthcare professional if you are breastfeeding or thinking of breastfeeding. CONTRAVE passes into breastmilk. You should not breastfeed while you are taking CONTRAVE.Opioid overdose:If you take opioids while taking CONTRAVE, the ingredient naltrexone in CONTRAVE
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