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Author: Admin | 2025-04-28
Toward abstinence after 7 weeks of therapy, so such therapy generally should be discontinued at that time in these patients.Combination Therapy with Extended-release Bupropion Hydrochloride Tablets and Transdermal Nicotine PatchesOralInitially, 150 mg daily, and after 3 days increase to 150 mg twice daily (with ≥8 hours between doses) while still smoking.After about 1 week of therapy, when the patient is scheduled to stop smoking, initiate transdermal nicotine therapy at a dosage of 21 mg/24 hours.Taper transdermal nicotine to 14, then to 7 mg/24 hours during the eighth and ninth weeks of therapy, respectively.Depression Associated With Bipolar Disorder† [off-label]Bupropion HydrochlorideOralDosages generally range from 75–400 mg in conjunction with a mood-stabilizing agent (e.g., carbamazepine, lithium, valproate).ADHD†Therapy with Conventional Bupropion Hydrochloride TabletsOralInitially, 150 mg daily. May be titrated up to 450 mg daily.Therapy with Extended-release Bupropion Hydrochloride TabletsOral150–450 mg daily.Prescribing LimitsAdultsMajor DepressionOralConventional bupropion hydrochloride tablets: Maximum 450 mg daily (not >150 mg per dose).Extended-release, film-coated bupropion hydrochloride tablets (e.g., Wellbutrin SR): Maximum 400 mg daily (not >200 mg per dose).Extended-release bupropion hydrochloride tablets (Wellbutrin XL): Maximum 300 mg daily.Extended-release, 450-mg bupropion hydrochloride tablets (Forfivo XL): Maximum 450 mg daily.Extended-release bupropion hydrobromide tablets (Aplenzin): Maximum 522 mg daily.Seasonal Affective DisorderOralExtended-release bupropion hydrochloride tablets (e.g., Wellbutrin XL): Dosages >300 mg daily not studied.Smoking CessationOralExtended-release (SR) bupropion hydrochloride tablets: 300 mg daily (not >150 mg per dose).Special PopulationsHepatic ImpairmentMaximum Dosage for Major Depression and Seasonal Affective Disorder in Moderate to Severe Hepatic Impairment (Child-Pugh score: 7–15)1142168Dosage FormMaximum DosageConventional bupropion hydrochloride tablets75 mg once dailyExtended-release, film-coated bupropion hydrochloride tablets (e.g., Wellbutrin SR)100 mg once daily or 150 mg every other dayExtended-release bupropion hydrochloride tablets (Wellbutrin XL)150 mg every other dayExtended-release bupropion hydrobromide tablets (Aplenzin)174 mg every other daySmoking cessation in patients with severe hepatic cirrhosis: Maximum 150 mg every other day as extended-release (SR) tablets .Major depression,
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