Allopurinol half life
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Thai or Korean descent), allopurinol should not be started unless there are no other filtration rate, allopurinol has a plasma half-life of about 1 to
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Allopurinol: Mechanism of Action and Safety. Allopurinol has an oral bioavailability of approximately 80% . It has a half-life of one hour, however, the half-life of the active metabolite oxypurinol is much longer at 23 h. Allopurinol is predominately excreted by the kidneys as its active metabolite oxypurinol . Xanthine oxidoreductase
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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neuropathy, neutropenia, and vacuolar my- opathy can develop in patients allopurinol. Allopurinol is metabolized in the liver and has a half-life
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The plasma half-life of allopurinol is 1-2 hours, due to its rapid renal clearance Label. The plasma half-life of allopurinol is 1-2 hours, due to its rapid
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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