To relieve constipation-predominant (IBS-C) symptoms chloride channel activators, guanylate cyclase activators, and the 5-HTnist are
by M Camilleri 2024 Cited by 42(cGMP), which activates chloride ion fully from the effects on enterocyte secretion of chloride ions, because the chloride channel activator, lubipro-.
Chloride channels modulate gastrointestinal neuromuscular functions in vitro. Lubiprostone, a selective type 2 chloride channel (ClC-2) activator, induces intestinal secretion and has been shown
DRUG CLASS: Gastrointestinal Chloride Channel Activators Amitiza is a type-2 chloride channel activator that stimulates chloride secretion in
Calcium-activated Chloride Channel Activators ; 4876, Eact ; Activator of Ca2-activated Cl- channel transmembrane protein 16A (TMEM16A)
Amitiza (lubiprostone) is a laxative used to treat chronic constipation and constipation caused by opioids. Amitiza is the only drug in the chloride channel activators class. Amitiza is the only drug in the chloride channel activators class.
Chloride channel activators stimulate intestinal fluid secretion without increasing serum electrolyte levels.
chloride-channel-activators Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 The Calcium-activated Chloride Channel. All Photos(
Chloride channel activators . Chloride channels located on intestinal epithelial cells regulate intestinal motility and fluid secretion. 92 Activation of type‐2 chloride channels triggers the release of chloride ions into the intestinal lumen. 92 The resulting ion gradient promotes sodium and water release into the lumen, increasing stool
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