Xa inhibitor drugs

Representative drugs of selective factor Xa inhibitors include fondaparinux, biotinylated idraparinux, rivaroxaban, apixaban and edoxaban. The former two are indirect factor Xa inhibitors, whereas the latter 3 are direct factor Xa inhibitors (Figure 1).

Apixaban, edoxaban, fondaparinux, and rivaroxaban are all Factor Xa inhibitors. List of Factor Xa inhibitors. View by Brand

Drug-specific anti-Xa activity assays calibrated for a single direct Xa inhibitor may be used to make quantitative measurements of drug level.

Apixaban, edoxaban, fondaparinux, and rivaroxaban are all Factor Xa inhibitors. List of Factor Xa inhibitors. View by Brand

Therefore, a factor Xa inhibitor could potentially have the properties of a desirable anticoagulant. Validating factor Xa as a drug target. The first factor Xa inhibitors. Although factor Xa was

Andexanet alfa is a biological agent a modified recombinant derivative of factor Xa that acts as a decoy receptor. It has a higher affinity for factor Xa inhibitor than natural Xa; consequently, the inhibitor binds to the drug rather than to natural Xa itself. It received the US Orphan Drug and FDA Breakthrough Therapy designations.

Laboratory testing and monitoring (dabigatran) Risks (dabigatran) DIRECT FACTOR Xa INHIBITORS. General considerations for direct factor Xa inhibitors - Differences between factor Xa inhibitors - Factor Xa inhibitors dosing - Factor Xa inhibitors toxicity - High BMI and post-bariatric surgery; Rivaroxaban - Overview (rivaroxaban)

Factor Xa inhibitors. Factor Xa inhibitors work on factor Xa in the coagulation cascade, which is responsible for converting the protein prothrombin into thrombin. Factor Xa inhibitors can affect factor Xa within the blood and also within a pre-existing clot. Factor Xa inhibitors do not require routine monitoring, unlike some other anticoagulants.

Direct factor Xa inhibitors block factor Xa's action in the common pathway and therefore inhibit coagulation. Available drugs include