High doses of methadone
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6.2. Buprenorphine versus Methadone. In the Cochrane meta-analysis, fixed-dose studies found neither significant difference on retention in treatment between medium dose buprenorphine to medium dose methadone, nor between high-dose buprenorphine and high-dose methadone. In contrast, flexible dosing, which describes doses increased as needed to
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High doses: Some individuals require methadone in high doses to be able to take care of the opiate addiction. Overdosing on doses exceeding 100
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– High dose ( 100 mg/d methadone). – Drug interactions that increase methadone exposure through inhibition of methadone metabolism. Eg
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6.2. Buprenorphine versus Methadone. In the Cochrane meta-analysis, fixed-dose studies found neither significant difference on retention in treatment between medium dose buprenorphine to medium dose methadone, nor between high-dose buprenorphine and high-dose methadone. In contrast, flexible dosing, which describes doses increased as needed to
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6.2. Buprenorphine versus Methadone. In the Cochrane meta-analysis, fixed-dose studies found neither significant difference on retention in treatment between medium dose buprenorphine to medium dose methadone, nor between high-dose buprenorphine and high-dose methadone. In contrast, flexible dosing, which describes doses increased as needed to
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6.2. Buprenorphine versus Methadone. In the Cochrane meta-analysis, fixed-dose studies found neither significant difference on retention in treatment between medium dose buprenorphine to medium dose methadone, nor between high-dose buprenorphine and high-dose methadone. In contrast, flexible dosing, which describes doses increased as needed to
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– High dose ( 100 mg/d methadone). – Drug interactions that increase methadone exposure through inhibition of methadone metabolism. Eg
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– High dose ( 100 mg/d methadone). – Drug interactions that increase methadone exposure through inhibition of methadone metabolism. Eg
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6.2. Buprenorphine versus Methadone. In the Cochrane meta-analysis, fixed-dose studies found neither significant difference on retention in treatment between medium dose buprenorphine to medium dose methadone, nor between high-dose buprenorphine and high-dose methadone. In contrast, flexible dosing, which describes doses increased as needed to
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