Bivalirudin half life

Bivalirudin is a direct thrombin inhibitor (anticoagulant) ^ half-life of elimination may be prolonged in renal or hepatic impairment.

by A Navaei 2024 Cited by 5While there are no reversal agents for bivalirudin, it has a much shorter half-life of 25 min in adults and 15 min in newborns, compared to heparin's half-life

Bivalirudin is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage, with a half-life in patients with normal renal function of 25 min. The disposition of bivalirudin was studied in PTCA patients with mild, moderate, and severe renal impairment.

half-life, ability for renal dose adjustment, and titration based on Effect of Direct Thrombin Inhibitors, Bivalirudin, Lepirudin, and Argatroban, on.

Bivalirudin and argatroban require Argatroban undergoes hepatobiliary excretion with an elimination half-life ranging 40 to 50.

half-life of 25 minutes and only 20% is excreted through the kidneys (12) d) Bivalirudin has a half-life of approximately 2 hours. 3. Compared to

Clearance was reduced by 21% in patients with moderate and severe renal impairment with a half-life of minutes, respectively. In dialysis patients, clearance was reduced by 70%, with a half-life of 3.5 hours. Approximately 25% bivalirudin is cleared by hemodialysis.

Pharmacokinetics are generally more predictable than those of heparin (especially bivalirudin, which doesn't bind to plasma proteins). Bivalirudin's short half-life (25 minutes) may make it easier to stop, compared to a heparin infusion (with half-life close to 45 minutes). disadvantages compared to heparin

Bivalirudin is a reversible direct thrombin inhibitor Elimination is predominantly by proteolytic enzyme inactivation (80%) whilst renal clearance accounts for approximately 20% of its elimination The initial clearance half-life of bivalirudin is 25 minutes. Clearance is not