Efficacy for the NNRTI drug class is reduced by mutations within or near the NNRTI binding pocket (NNIBP). Drug resistance poses a considerable challenge in anti-HIV-1 drug discovery. Among the approved NNRTIs drugs, EFV, RPV, and DOR are approved in combination with NRTIs or integrase strand transfer inhibitor (INSTI) to overcome viral resistance.
NNRTIs are also active against some nucleoside-resistant strains; for example NNRTI class of drugs (150). The clinical significance of this phenomenon
drugs, for example 3TC, from being incorporated during reverse transcription. Drug resistance to NNRTIs can emerge quickly following the start
The most common side effects of NNRTIs are fat redistribution, elevation of liver enzymes, and a mild rash . Although each NNRTI drug is different in its
brief, each of these drug classes is described below, as are examples of new drugs under development: NNRTIs. NNRTIs (non-nucleoside reverse transcriptase.
by KA Kellick 2024 Cited by 193Rosuvastatin drug interactions. 24. AstraZeneca. Crestor (rosuvastatin Concomitant drug class/name, NNRTI, Effect on NNRTI or concomitant drug
by SJ Smith 2024 Cited by 22The five approved NNRTI drugs are: nevirapine (NVP. Open Access HIV-1 drug resistance mutations and risk of NNRTI-based antiretrovi- ral treatment
by JSA Stringer 2024 Cited by 70(NNRTI) drugs. This drug resistance largely fades over time. We (NNRTI) class of antiretroviral drugs [11],[12]. Population
by RK Gupta 2024 Cited by 440resistant virus, with most resistance to the NNRTI drug class.6 antiretroviral drugs at the time of re-initiating NNRTI- based ART
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