Naltrexone and gabapentin

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Actual: dependent patients were randomly assigned to receive naltrexone plus active gabapentin (N=50), naltrexone plus placebo gabapentin (N=50), or placebo naltrexone and placebo gabapentin (N=50), using a double dummy placebo-controlled medication design. Naltrexone or its matching placebo was given as 25 mg for 2 days and then
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Gabapentin also had preliminary efficacy as an add-on to naltrexone; in a trial of 150 alcohol-dependent subjects randomized to naltrexone (50 mg/day, n = 50) alone, naltrexone and gabapentin (up to 1,200 mg/day, n = 50) or double placebo (n = 50), the combined naltrexone/gabapentin group delayed the time to first HDD and decreased the number

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JThe addition of gabapentin to naltrexone improved drinking outcomes compared with naltrexone alone in heavy drinkers during

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The combination of gabapentin and naltrexone was well tolerated. Again, the absence of a gabapentin alone group in the study design precludes assessment of gabapentin efficacy, but the group that received gabapentin in combination with naltrexone had better outcomes on several measures of drinking, craving and sleep than naltrexone alone or

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The addition of gabapentin to naltrexone improved drinking outcomes over naltrexone alone during the first 6 weeks after cessation of drinking. This effect did not endure after gabapentin was discontinued.

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Combining gabapentin and naltrexone may also help counteract some naltrexone side effects, such as insomnia and mood problems. 7 Finally, gabapentin can ease initial alcohol withdrawal symptoms and make it easier for people to transition to daily naltrexone or the Sinclair Method.

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The addition of gabapentin to naltrexone improved drinking outcomes over naltrexone alone during the first 6 weeks after cessation of drinking. This effect did not endure after gabapentin was discontinued.

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Gabapentin and naltrexone were administered concomitantly for the first 6 weeks and then discontinued. Naltrexone was continued for another 10

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Gabapentin also had preliminary efficacy as an add-on to naltrexone; in a trial of 150 alcohol-dependent subjects randomized to naltrexone (50 mg/day, n = 50) alone, naltrexone and gabapentin (up to 1,200 mg/day, n = 50) or double placebo (n = 50), the combined naltrexone/gabapentin group delayed the time to first HDD and decreased the number

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Gabapentin also had preliminary efficacy as an add-on to naltrexone; in a trial of 150 alcohol-dependent subjects randomized to naltrexone (50 mg/day, n = 50) alone, naltrexone and gabapentin (up to 1,200 mg/day, n = 50) or double placebo (n = 50), the combined naltrexone/gabapentin group delayed the time to first HDD and decreased the number

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