Methadone is safe in pregnancy and in breastfeeding. DISCHARGE - Methadone may not be prescribed for OUD. Must be administered in a methadone clinic - Naloxone 4mg/0.1ml After initial 72 hours: cont same dose for 5 days, can increase dose by 10mg q5days Day 1: Max dose 40mg YES YES If no sedation give mg methadone
Calculate starting lorazepam dose: Midazolam: Multiply current midazolam drip rate (mg/kg/h) X 0.5 = _____ mg/kg lorazepam q6h (max initial dose 0.2 mg/kg/dose q6h AND max 4 mg q6h) Weaning Methadone and Lorazepam Once stable on methadone and/or lorazepam for 24 h with no withdrawal symptoms, wean methadone and lorazepam as follows. Methadone
Bao, A meta-analysis of retention in methadone maintenance by dose and dosing ○ 30mg is max single dose and 40mg is max total daily dose at
Max 3 doses in 24hrs. On day 4/5 – doses consolidated. Hold 10mg PRN dose Methadone 40mg PO OD starting dose. Addition of Hydromorphone IR
The methadone max dose for pain for the starting dose is 20 mg per day. In the case of elderly patients, the upper limit is 10 mg per day.
Calculate starting lorazepam dose: Midazolam: Multiply current midazolam drip rate (mg/kg/h) X 0.5 = _____ mg/kg lorazepam q6h (max initial dose 0.2 mg/kg/dose q6h AND max 4 mg q6h) Weaning Methadone and Lorazepam Once stable on methadone and/or lorazepam for 24 h with no withdrawal symptoms, wean methadone and lorazepam as follows. Methadone
Grapefruit juice. Carbamazepine. Phenytonin. Rifampicin/rifampin. St Methadone 10mg q3h PRN. Max 3 doses in 24hrs. On day 4/5 – doses
The methadone max dose for pain is 100mg daily. The use of this medication higher than this dose would result in an overdose which has its signs
Max 3 doses in 24hrs. On day 4/5 – doses consolidated. Hold 10mg PRN dose Methadone 40mg PO OD starting dose. Addition of Hydromorphone IR
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