Volume of distribution of drugs

Volume of distribution is the measure of the apparent space in the body available to contain the drug. Volume of distribution (V) relates the

Volume of distribution is the total amount of drug in systemic circulation divided by the plasma drug concentration. It conceptualizes the volume of tissue that

A drug can be characterised by the volume of fluids into which it distributes . Since the volume of body fluids cannot be easily measured, it is assumed that the body simplifies into a tank of fluid into which the drug is placed. This volume is known as s$% ? the volume of distribution (V d).

examples, drug excipient interaction Drug interactions, drug distribution, antagonist, distribution volume, protein binding, agonist

Drug distribution Volume of distribution. The volume of distribution (Vd) is a theoretical concept that describes the apparent volume that a drug disperses into to produce the observed plasma concentration. It assumes that a drug is distributed evenly among one compartment.

The formula for half-life is: t1/2= [(0.693)(Volume of distribution)]/Clearance or. t1/2= [(0.693)(Vd)]/Cl. The half-life is directly proportional to the volume of drug distribution. It means the more the drug is distributed in the body, the more the half-life is.

This value is then multiplied by body weight to obtain a person s volume of distribution. A 35-kg child will thus have a volume of distribution of a drug half that of a typical 70-kg standard adult male. The volume of distribution expressed in this way is assumed to be a constant for a drug, assuming normal conditions and health.

The AUC of morphine is nmolh/L. Volume of distribution. The volume of distribution of morphine is 5.31L/kg. Morphine-6-glucuronide

In both models, distribution is referred to as the volume of distribution (Vd) since volume is a convenient metric to compartmentalize the distribution of solutes, including drugs. The volume of distribution can be an important indicator of changes in bioavailability.