More on the risk factors for thiamine deficiency above. 100 mg IV/IM thiamine daily is often used for this purpose (in the absence of any high-level evidence). Oral thiamine is probably adequate for this purpose as well (with advantages regarding reduced cost and ease of administration).
Thiamine deficiency and cardiovascular disorders . One time administration of 100 mg IV thiamine, improved endothelium-dependent vasodilatation in 10 patients with TD2 during an acute glucose tolerance test. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study .
Parenteral administration (intermittent infusion and IV push) of thiamine has minimal safety concerns with a few allergic reactions reported, however; it has been associated with uncommon cases of angioneurotic edema, anaphylactic shock, and cardiac arrest. 6,7 Current literature suggests thiamine up to 250 mg is most likely safe to be administrated as an IV push.
Thiamine Deficiency thiamine 500 mg IV infusion over 30 minutes, 3 times daily for 3 days then thiamine 250 mg IV or IM, daily for 3 to 5 days
IV Vitamin Administration: B1 with Your Medications : Parenteral vitamins, thiamine, and FDA guidelines. Article Buy $10.95. Publication Date: 1
levofloxacin 500 mg IV q24h 750 mg IV q24h 500 mg PO q24h 750 mg PO q24h Avoid concurrent divalent and trivalent cation administration 2 hours before or 6 hours after. Avoid administration with tube feeds. linezolid 600 mg IV q12h 600 mg PO q12h metronidazole 500 mg IV q8h 500 mg PO q8h Thiamine IV (dose equivalent) Thiamine PO (dose equivalent
Loading doses (rapid administration of initial high doses) of IV diazepam or lorazepam are recommended, as are IV thiamine (prior to IV glucose) and multiple vitamins. The physician should consider intramuscular or intravenous haloperidol (Haldol and others) to treat agitation and hallucinations.
levofloxacin 500 mg IV q24h 750 mg IV q24h 500 mg PO q24h 750 mg PO q24h Avoid concurrent divalent and trivalent cation administration 2 hours before or 6 hours after. Avoid administration with tube feeds. linezolid 600 mg IV q12h 600 mg PO q12h metronidazole 500 mg IV q8h 500 mg PO q8h Thiamine IV (dose equivalent) Thiamine PO (dose equivalent
Further, blood thiamine concentrations approaching those seen with IV administration were achieved within 1 week of initiating oral thiamine
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