Leucovorin and methotrexate

☑️@leucovorin_and_metho · 8793 subscribers · Content 18+ 🔞
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Actual: methotrexate, pyrimethamine, and trimethoprim; and for leucovorin rescue after high doses of methotrexate. Investigational: adjunct with 5-fluorouracil to
4.6 rating 2025-04-25
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Leucovorin is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses.

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Leucovorin is also given with a chemotherapy agent called methotrexate, but in this case, it is given to rescue normal, healthy cells from the damage caused by the methotrexate. In order to give the methotrexate time to kill the cancer cells, leucovorin is started hours after the methotrexate is given.

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Leucovorin is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses.

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Leucovorin Rescue After High-Dose Methotrexate Therapy. The recommendations for leucovorin rescue are based on a methotrexate dose of 12 to 15 grams/m 2 administered by intravenous infusion over 4 hours (see methotrexate package insert for full prescribing information). 4

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Leucovorin Calcium for Injection rescue is indicated after high dose methotrexate therapy in osteosarcoma. Leucovorin Calcium for Injection is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists.

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Leucovorin is a medication used in the treatment of methotrexate toxicity and chemotherapy regimens. Leucovorin is a folate analog. This activity reviews the indications, action, and contraindications for leucovorin as a valuable agent in the reversal of methotrexate toxicity and as a part of chemotherapy regimens. This activity will highlight the mechanism of action, adverse event profile

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It is important not to underdose the leucovorin: It is safe, and methotrexate is very toxic. Leucovorin should be administered as soon as

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High-Dose Methotrexate, Leucovorin and Glucarpidase Dosing, Administration, and Monitoring - Adult/Pediatric - Inpatient

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Leucovorin Rescue after High-Dose Methotrexate Therapy. The recommendations for leucovorin rescue are based on a methotrexate dose of 12 to 15 grams/m2 administered by intravenous infusion over 4 hours (see methotrexate package insert for full prescribing information).

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